Creation of a new biodegradable polymer could lead to stronger medical implants

Creation of a new biodegradable polymer could lead to stronger medical implants

Polylactic acid, or PLA, is a biodegradable polymer commonly used to make a variety of products from disposable cups to medical implants to drug delivery systems.

A team of Brown University researchers has shown that by treating PLA at various temperatures and pressures, they can induce a new polymer phase in the material – one that could possibly decrease the rate at which it degrades. The findings are published in the journal Polymer.

“It’s an exciting finding from the standpoint of basic science, in that we’ve found a new polymer phase and have identified a method for inducing it,” said Edith Mathiowitz, a professor of medical science and engineering at Brown. “In terms of applications, the polymer we worked with in this study has many uses, and we believe the properties we have discovered now will allow us to make it better.”

PLA is a semi-crystalline material, and work by previous researchers had shown that treating PLA with heat could increase the material’s crystalline makeup, which could help to increase its strength. Researchers in Mathiowitz’s lab, led by doctoral candidate Christopher Baker, wanted to see if adding pressure to the treatment process would further influence the material’s structure.

Baker treated PLA samples under a variety of different temperature and pressure conditions for varying amounts of time. Pressures ranged from 2,000 to 20,000 pounds per square inch. Temperatures used for treatments were above, below and nearly equal to the glass transition temperature for PLA – the temperature at which the amorphous parts of the material transition from solid to rubbery.

Baker showed that the treatments increased the amount of crystalline area in the material, but there was another more surprising finding. At higher temperatures and pressures, the amorphous parts of the material became birefringent, meaning that they bend light differently depending upon how the light is polarized. That is an indicator of a substantial structural change in the amorphous portions of the material.

Baker then used several methods to further characterise how the amorphous regions had changed. Using X-ray diffraction he showed that polymer strands in some of the amorphous sections had become dramatically more ordered. Further thermal analysis showed that the more ordered sections had a higher glass transition temperature. In general, amorphous materials with higher glass transition temperatures degrade at significantly slower rates.

The new amorphous phase combined with the overall increase in crystallinity in the treated samples could have significant implications for the material’s mechanical properties, the researchers said. The higher crystallinity could make it stronger, while the more ordered amorphous sections could make it last longer. That slower rate of degradation could be particularly useful in medical applications, an area in which Mathiowitz’s lab specializes.

There is interest in using PLA for plates and screws used to stabilise broken bones. The advantage to PLA implants is that they degrade over time, so a patient would not need a second surgery to remove them. PLA may degrade too quickly for some of these applications, but if this new polymer phase slows degradation, it may become a better option.

Source: Brown University

 

Reference: Baker, C.M., Azagury, A. & Mathiowitz, E. Effect of pressure on poly-l-Lactic Acid morphology. Polymer, 2016; 99: 250 DOI: 10.1016/j.polymer.2016.07.028

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