The ability of the commonly used stimulant methylphenidate (Ritalin) to speed recovery from general anaesthesia appears to apply both to the inhaled gas isoflurane, as previously reported, and to the intravenous drug propofol. Members of the same Massachusetts General Hospital (MGH) research team that reported the isoflurane study are publishing similar results for propofol in Anesthesiology, and their paper has been issued online.
“Propofol is the most widely used intravenous general anaesthetic, and there is currently no way to reverse its effects,” says Ken Solt, MD, of the MGH Department of Anaesthesia, Critical Care and Pain Medicine, the paper’s corresponding author. “By finding that methylphenidate can reverse general anaesthesia with propofol as well as with isoflurane, we show that it may be broadly applicable for waking patients up from different general anaesthetic drugs.”
The MGH team’s previous study, published in Anesthesiology, showed that methylphenidate – known to affect arousal pathways in the brain and commonly used to treat attention-deficit hyperactivity disorder – significantly decreased the amount of time it took for rats to recover from isoflurane anaesthesia. The current study ran very similar experiments, in which propofol, which has a different mechanism of action than isoflurane, was the anaesthetic agent.
In the first experiments, animals that had lost consciousness after a single dose of propofol were given intravenous methylphenidate or saline, and those receiving methylphenidate recovered almost five minutes faster than those receiving saline. Administration of methylphenidate also induced signs of arousal – movement or standing up – in rats receiving a constant intravenous dose of propofol, while animals administered saline remained motionless. EEG readings of the brains of animals during constant infusion of a higher propofol dose showed that methylphenidate caused brain activity to shift back toward the awake state. The change persisted for up to ten minutes, during which the animals showed signs of arousal like opening their eyes and kicking, although they did not stand up.
“Propofol can be a very dangerous drug because it can cause patients to stop breathing and their blood pressure to drop,” Solt explains. “It is often used for sedation during procedures such as colonoscopies, and if patients get oversedated, methylphenidate may be useful in getting them to wake up and resume breathing and in restoring their blood pressure. In the operating room, where propofol can be administered for several hours, patients may take as long as an hour to recover. The ability to use methylphenidate to induce recovery could make general anaesthesia safer and more efficient, and we’re hoping to conduct a clinical trial in patients in the near future.”