By: 19 February 2016
New imaging technique could reduce need for amputation

New imaging technique could reduce need for amputation

A new imaging technique could reduce the need for amputation in patients with critical limb ischemia, according to a study published in January in the scientific journal JACC.

British Heart Foundation (BHF) funded researchers at St Thomas’ Hospital, London have developed a new way of mapping blood delivered to the leg muscle immediately after operations on people with severely reduced blood flow to their limbs. Currently surgeons may need to wait days or weeks to see how successful the surgery has been.

They hope that the new technique will ultimately reduce the need for amputations, which can be needed if blood flow cannot be restored.

This surgery is used to treat critical limb ischemia (CLI) – a serious condition which occurs when the arteries in the limbs become blocked, dramatically reducing blood flow to the feet and legs. Up to 30 per cent of patients with CLI eventually have to have the affected limb amputated (1).

In order to treat CLI the blocked part of the artery has to be either bypassed during surgery or widened using a small piece of expandable mesh called a stent.

During the study researchers used the new MRI-based mapping technique to determine how much blood was reaching the muscles in the legs of 34 people with CLI, before and after treatment and in 22 healthy people. They then obtained a small amount of leg muscle using a biopsy, in order to check that the results provided by the new technique were correct.

Surgeon, Mr Bijan Modarai, who led the research, hopes that the new technique could eventually be used to immediately see how much blood flow to the limb had been improved. Currently, the only way of determining the success of surgery is to wait for a period of days to see whether the leg improves.

Mr Bijan Modarai, BHF Intermediate Fellow and Reader/Consultant in Vascular Surgery at King’s College London/St Thomas’ Hospital, lead author of the study, said:

“Here at Guy’s and St Thomas’ NHS Foundation Trust we treat over 500 people with critical limb ischaemia each year. By using this new imaging technique we hope to be better placed to offer the best possible treatment to people suffering from this disease and therefore reduce the likelihood of limb amputation.”

Professor Jeremy Pearson, Associate Medical Director at the BHF, said: “The strength of this study is that it shows that this new imaging technique could be used widely to accurately show whether blood flow to the small vessels in the leg is improved sufficiently by stenting or bypass surgery. By using this technique surgeons will quickly gain a clear indication of whether treatment has been successful.”