Visceral obesity is a risk factor for bone loss and decreased bone strength in men, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).
“It is important for men to be aware that excess belly fat is not only a risk factor for heart disease and diabetes, it is also a risk factor for bone loss,” said Miriam Bredella, MD, radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston.
According to the US National Center for Health Statistics, more than 37 million American men over age 20 are obese. Yet despite all the health issues, it was commonly accepted that men with increased body weight were at lower risk for bone loss.
“Most studies on osteoporosis have focused on women. Men were thought to be relatively protected against bone loss, especially obese men,” Dr Bredella said.
After the Osteoporotic Fractures in Men Study indicated that male obesity was associated with fracture risk, the researchers wanted to quantify belly fat and study its impact on bone strength.
Dr Bredella and her team evaluated 35 obese men with a mean age of 34 and a mean body mass index (BMI) of 36.5. The men underwent CT of the abdomen and thigh to assess fat and muscle mass, as well as very high resolution CT of the forearm and a technique called finite element analysis (FEA), in order to assess bone strength and predict fracture risk.
“FEA is a technique that is frequently used in mechanical engineering to determine the strength of materials for the design of bridges or airplanes, among other things,” Dr Bredella said. “FEA can determine where a structure will bend or break and the amount of force necessary to make the material break. We can now use FEA to determine the strength or force necessary to make a bone break.”
In the study, the FEA analysis showed that men with higher visceral and total abdominal fat had lower failure load and stiffness, two measures of bone strength, compared to those with less visceral and abdominal fat. There was no association found between age or total BMI and bone mechanical properties.
“We were not surprised by our results that abdominal and visceral fat are detrimental to bone strength in obese men,” Dr Bredella said. “We were, however, surprised that obese men with a lot of visceral fat had significantly decreased bone strength compared to obese men with low visceral fat but similar BMI.”
The results also showed that muscle mass was positively associated with bone strength.
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