By: 29 April 2015
Fibrin glue is effective scaffold for stem cell implantation in osteoarthritic knees

Fibrin glue is effective scaffold for stem cell implantation in osteoarthritic knees

The findings of a recent study published in the American Journal of Sports Medicine have shown that fibrin glue is an effective scaffold for mesenchymal stem cell implantation when treating patients with osteoarthritic knees.
Researchers at the Yonsei Sarang Hospital in Seoul, Korea, retrospectively evaluated the outcomes of 54 patients who underwent second-look arthroscopy after mesenchymal stem cell (MSC) implantation for the treatment of lesions in their osteoarthritic knees. Patients were divided into two groups: the first included 37 patients who underwent MSC implantation without a scaffold, whereas the second included 17 patients who underwent MSC implantation with fibrin glue used as a scaffold.
Using pre- and postoperative International Knee Documentation Committee (IKDC) and Tegner activity scale scores, the researchers evaluated the patients’ clinical outcomes. The International Cartilage Repair Society (ICRS) grading system was used to evaluate the repair of cartilage lesions, and prognostic factors associated with clinical and second-look arthroscopic outcomes were identified through statistical analyses. Mean follow-up was at 28.6 months.
The study found that patients in both treatment groups experienced significant improvements in mean IKDC scores, with the first group’s score increasing from 38.1 preoperatively to 62 postoperatively, while the second group’s score increased from 36.1 to 64.4 between the pre- and postoperative periods. Tegner scores also improved significantly in both groups. In addition, nine of the 39 lesions in the first group and 12 of the 17 lesions in the second achieved an ICRS cartilage repair grade of 1 or 2.
Being overweight and having a large lesion size were found to be predictors of poor arthroscopic outcomes in the first group. Although a similar trend was observed in the second group, the differences were not considered significant. To learn about Adderall and how it works please visit this Adderall online website for buying
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Kim, Y.S., Choi, Y.J., Suh, D.S., et al. Mesenchymal stem cell implantation in osteoarthritic knees: Is fibrin glue effective as a scaffold? Am. J. Sports Med. 2014;doi:10.1177/0363546514554190.