Stress injuries to the spinal cord, like spinal cord ischemia or reperfusion injury, lead to the expression of stress-related proteins in neurons. These could be of great significance for establishing pathological mechanism and control measures.
Previous studies identified 21 differentially expressed proteins in rabbits with spinal cord injury using differential proteomics.
Of these, stress-related proteins included protein disulfide isomerase A3, stress-induced-phosphoprotein 1 and heat shock cognate protein 70. These were expressed only in cytoplasm but not in the nuclei, suggesting that the expression of stress-related proteins exhibited a protective effect on neurons.
After spinal cord injury, heat shock cognate protein 70 expression was detectable in glial cell nuclei in the gray matter and in Schwann cell nuclei in the white matter, possibly because this protein was transported back into nuclei. These findings were published in the Neural Regeneration Research.